The Biggest NFL Injuries Of 2025

NFL: DEC 14 Chargers at Chiefs — Source: Icon Sportswire / Getty

We all love sports. Real talk – there’s nothing like that rush you get when your team scores, the sound of the crowd losing its mind, and those NFL Sundays that feel like holy days. We live for the highlights, the thrilling wins, the buzzer-beaters, the game-winning touchdowns, and the impossible comebacks. Sports bring us together, give us stories to tell, and make ordinary days feel blessed with possibility. But we hate to see NFL injuries, regardless of whether or not it’s a player on your team.

Ironically, something we love this much can still hurt us so bad. We’ve all felt that pain when our team loses a close one. We’ve heard rumors about trades and felt that sting when a favorite player gets shipped off. But nothing in sports hurts deeper than seeing our heroes go down with a serious injury. It’s one thing to lose a game; it’s another thing to see someone you root for physically hurt.

Yeah, injuries are part of the game. Coaches, players, doctors, commentators – they’re always reminding us of that. But that doesn’t make it easy. When a top star hits the turf and doesn’t get up, the vibe shifts. A collective sigh washes over the league—fans, analysts, even rival teams feel it. We watch our favorites compete not just for victory, but for their own bodies. When those bodies break, the heartbreak cuts deep.

No moment this year captured that gut-punch feeling like what happened this past Sunday when Patrick Mahomes—a leader, a legend, one of the faces of our generation—went down with a gruesome knee injury. What was supposed to be another thrilling Chiefs playoff push instead turned into silence at Arrowhead Stadium, followed by confirmation of a torn ACL. The injury didn’t just end Mahomes’ season; it shook the entire league’s soul, ended the Chiefs’ playoff hopes this year, and will likely keep the 2x league MVP out of action for a good part of next year. He’s not the only big name who got hurt this year, though. The 2025 NFL season has been marred by devastating injuries from coast to coast, sidelining stars from the trenches to the skill positions. It’s reminded everyone, fans and players alike, that even in a game built on toughness, the human body still has limits. Pain is real, especially when it steals moments we knew we were born to watch.

Below, check out a list of the most notable injuries this season. Speedy recovery to all of the players!

Patrick Mahomes – QB, Kansas City Chiefs

Injury: Torn ACL (left knee) – season-ending.
Date & Opponent: December 14, 2025 vs. Los Angeles Chargers.
Details: Mahomes suffered a torn ACL late in the fourth quarter while trying to extend a play; it ended his 2025 season and eliminated the Chiefs from playoff contention. He underwent successful surgery to repair the ACL (and reportedly LCL), and rehab has begun. He’s projected to be out at least 9 months, which could impact the start of the 2026 season.

Micah Parsons – LB/Edge, Green Bay Packers

Injury: Torn ACL (left leg) – season-ending.
Date & Opponent: December 14, 2025 vs. Denver Broncos.
Details: Parsons went down with a non-contact knee injury in the third quarter. MRI confirmed a torn ACL, ending his 2025 campaign and threatening to keep him out well into 2026. This is a massive blow to Green Bay’s defense and its playoff outlook.

Tyreek Hill – WR, Miami Dolphins

Injury: Knee dislocation + multiple ligament tears (including ACL) – season-ending.
Date & Opponent: September 29, 2025 vs. New York Jets.
Details: Hill suffered a gruesome knee injury that included a dislocation and multiple torn ligaments. He underwent major surgery and was ruled out for the rest of the season, though reports suggest he’s expected to target a return in 2026 after recovery.

Nick Bosa – DE, San Francisco 49ers

Injury: Torn ACL (right knee) – season-ending.
Date & Opponent: September 21, 2025 vs. Arizona Cardinals.
Details: The 49ers confirmed that Bosa suffered a torn ACL early in the game, forcing him out for the rest of the 2025 season and requiring surgery. This was a devastating loss for San Francisco’s defense, removing one of the league’s premier edge rushers.

Malike Nabers – WR, New York Giants

Injury: Torn ACL (right knee) – season-ending.
Date & Opponent: September 28, 2025 vs. Los Angeles Chargers.
Details: Nabers went down with a severe knee injury in the second quarter of the Giants’ win. An MRI later confirmed a torn ACL, ending his 2025 season and leaving the Giants without their top offensive weapon.

Tucker Kraft – TE, Green Bay Packers

Injury: Torn ACL (right knee) – season-ending.
Date & Opponent: November 2, 2025 vs. Carolina Panthers.
Details: Kraft suffered a season-ending torn ACL in his right knee after a valgus force impacted his straight leg during a block. He was carted off the field and an MRI confirmed the ACL tear, ending his 2025 season, with expectations to return for the 2026 season after rehabilitation.

Zach Ertz – TE, Washington Commanders

Injury: Torn ACL (right knee) – season-ending.
Date & Opponent: December 7, 2025 vs. Minnesota Vikings.
Details: Ertz suffered a devastating knee injury when his leg buckled while attempting to make a catch. He was placed on IR (injured reserve) a few days later after an MRI confirmed a torn ACL, ending his 2025 campaign.

Najee Harris – RB, Los Angeles Chargers

Injury: Torn Achilles tendon – season-ending.
Date & Opponent: September 21, 2025 vs. Denver Broncos.
Details: Harris suffered a non-contact torn Achilles in Week 3, instantly ending his 2025 season. This came after he had just returned from an offseason placement on the non-football injury list due to an eye issue. He’ll need extensive rehab, with an extended absence projected.

Daniel Jones – QB, Indianapolis Colts

Injury: Torn Achilles tendon – season-ending.
Date & Opponent: December 7, 2025 vs. Jacksonville Jaguars.
Details: Jones suffered a severe Achilles tear late in the first quarter while attempting a pass, abruptly ending his breakout season after a strong stretch as the leader of the Colts’ offense. He underwent surgery and is expected to be sidelined for several months into the 2026 season.

Marshon Lattimore – CB, Washington Commanders

Injury: Torn ACL (right knee) – season-ending.
Date & Opponent: November 2, 2025 vs. Seattle Seahawks.
Details: Lattimore suffered a season-ending torn ACL in his knee, requiring surgery and a lengthy rehab, likely keeping him out until the 2026 season, following previous issues with a hamstring injury earlier in the year.

The Biggest NFL Injuries Of 2025